Innovative simulation tool for bone and bone biomaterials, based on enhanced CT-data exploitation

Publications


Scientific Basis for Project Developments

A. Fritsch, Ch. Hellmich: "'Universal' Microstructural Patterns in Cortical and Trabecular, Extracellular and Extravascular Bone Materials: Micromechanics-Based Prediction of Anisotropic Elasticity"; Journal of Theoretical Biology, 244 (2007), 4; p. 597 - 620.  

St. Scheiner, R. Sinibaldi, B. Pichler, V. Komlev, C. Renghini, C. Vitale-Brovarone, F. Rustichelli, Ch. Hellmich: "Micromechanics of Bone Tissue-Engineering Scaffolds, Based on Resolution Error-Cleared Computer Tomography"; Biomaterials, 30 (2009), p. 2411 - 2419. 

Ch. Hellmich, C. Kober, B. Erdmann: "Micromechanics-Based Conversion of CT Data into Anisotropic Elasticity Tensors, Applied to FE Simulations of a Mandible"; Annals of Biomedical Engineering, 36 (2008), 1; p. 108 - 122.  

Project Results

Journal Papers

T. Brynk, Ch. Hellmich, A. Fritsch, P.K. Zysset, J. Eberhardsteiner: "Experimental Poromechanics of Trabecular Bone Strength: Role of Terzaghi's Effective Stress and of Tissue Level Stress Fluctuations"; Journal of Biomechanics, 44 (2011), p. 501 - 508.

J. Vuong, Ch. Hellmich: "Bone Fibrillogenesis and Mineralization: Quantitative Analysis and Implications for Tissue Elasticity"; Journal of Theoretical Biology, 287 (2011), S. 115 - 130.

A. Dejaco, V. Komlev, J. Jaroszewicz, W. Swieszkowski, Ch. Hellmich: undefined“Micro CT-based multiscale elasticity of double porous (pre-cracked) hydroxyapatite granules for regenerative medicine”; Journal of Biomechanics, (2012), in print

A. Fritsch, Ch. Hellmich, P. Young: “Micromechanics-derived scaling relations for poroelasticity and strength of brittle porous polycrystals”; Journal of Applied Mechanics, (2012), accepted

 

Proceedings Papers

A. Fritsch, Ch. Hellmich, Ph. Young: "undefinedPorosity-dependent Elasticity and Strength of Ceramic Bone Biomaterials: Micromechanics-based Assessment of Power Functions"; Proceedings of the IASTED International Conference Biomedical Engineering (Biomed 2011), p. 156-162.

J. Jaroszewicz, B. Ostrowska, V. Komlev, J. Hostens, Ch. Hellmich, W. Swieszkowski, K.J. Kurzydlowski: "undefinedMicro and Nano-CT measurements of biomaterials for bone tissue engineering"; Micro-CT User Meeting, Sky Scan, Belgium (2011), p. 97-100.

J. Dyson, V. Calbucci, F. Pasqualini, G. Albertini, F. Fiori, F. Rustichelli: "undefinedSoftware clearing CT data from effects of intrumental resolution"; Micro-CT User Meeting, Sky Scan, Belgium (2011), p. 101-107.

A. Fritsch, A. Dejaco, V. Komlev, W. Swieszkowski, J. Jaroszewicz, E. Bongaers, Ch. Hellmich: "undefinedTranslation of CT data into voxel-specific micromechanics-based elasticity tensors"; Micro-CT User Meeting, Sky Scan, Belgium (2011), p. 108-112.

C. Kober, H. von der Kammer, W. Swieszkowski, J. Jaroszewicz, Ch. Hellmich: "undefinedMultiscale visualization of biomaterials based on SkyScan-uCT"; Micro-CT User Meeting, Sky Scan, Belgium (2011), p. 299-304.

undefinedSeminar "BIO-CT-EXPLOIT: CT-based bone biomechanics", CADFEM User Meeting, Stuttgart, Germany, 21.10.2011.

J. Dyson, V. Calbucci, F. Pasqualini: “undefinedSoftware for clearing CT data from effects of instrumental resolution”; 2011 Simpleware User Meeting, Bristol, UK, 09.11.2011

A. Fritsch, Ch. Hellmich and P. Young: “undefinedMicromechanics-derived scaling relations for poroelasticity and strength of brittle porous polycrystals”; 2011 Simpleware User Meeting, Bristol, UK, 09.11.2011.

A. Dejaco, V.S. Komlev, J. Jaroszewicz, W. Swieszkowski and C. Hellmich: “undefinedMicro CT-based multiscale elasticity of double-porous (pre-cracked) hydroxyapatite granules for regenerative medicine”; 2011 Simpleware User Meeting, Bristol, UK, 09.11.2011.

J. Jaroszewicz, V. Komlev, C. Hellmich and W. Swieszkowski: “undefinedCombined use of μ-CT and in-situ mechanical testing to characterize the ceramic-based biomaterials for regenerative medicine”; 2011 Simpleware User Meeting, Bristol, UK, 09.11.2011.

C. Kober, C. Mueller, P. Young, A. Fritsch, and Ch. Hellmich: “undefinedSoftware for reconstruction of anisotropic trajectories of elasticity for bony organs based on kind of inner skeleton”; 2011 Simpleware User Meeting, Bristol, UK, 09.11.2011.